DNA实验免疫细胞表面抗原分子CD家族对照表CD1CD24.docx
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DNA实验免疫细胞表面抗原分子CD家族对照表CD1CD24.docx
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DNA实验免疫细胞表面抗原分子CD家族对照表CD1CD24
免疫细胞表面抗原分子CD家族对照表(CD1-CD247)
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Note:
noinformationisavailableonCDw145,CD181,CD182,CD185-194,CD196-199,CD211,CD214-216,CD218-220, CD237
Background
CD:
clusterdesignationofmonoclonalantibodies(clustersofdifferentiation)
Designatedatthe1stto7thWorkshopsonInternationalHumanLeukocyteDifferentiationAntigens
Thelastconferencewasin2000.Thenextconferenceisin2004.
HLDAWorkshopsaretheprimarymechanismtocharacterizeleukocytesurfaceantigenicmoleculesandepies;erythroidantigensarenowincluded
For1stto6thworkshops,antibodiesweresubmittedtotheorganizinglaboratory,codedandsenttoparticipatinglaboratoriesfortestingagainst various cell types.Forthe7thworkshop,aCDdesignationcouldbeestablishedforamoleculeifitsgenehas beenclonedandatleastonespecificmonoclonalantibodyhad beenstudiedintheWorkshop
Interpretationshouldbebasedoncellulardistributionofstaining,proportionofpositivelystainedcells,stainingintensityandcutofflevels.
CD1
Familyofnon-polymorphicMHCclassI-likeglycoproteins
Alsomemberofimmunoglobulinsuperfamily
Onchromosome1q22-23(notMHClinked)
Has5differentsubsets,allnoncovalentlyassociatedwith12kdbeta2microglobulin
Function:
restrictTcellresponsestocertainantigens;maymediatethymicTcelldevelopment
Positivestaining(normal):
corticalthymocytes(70%),activatedTcells,Langerhanscells,interdigitatingdendriticcells
Positivestaining(disease):
preTALLwithcorticalthymocytephenotype;Langerhanscellhistiocytosis
Negativestaining:
matureperipheralTcells
CD1a
Positivestaining(normal):
Dendriticcellsindermis/epidermisofbenigninflammatoryskindisorders
Positivestaining(disease):
Langerhanscellhistiocytosis(fairlyspecific),myeloidleukemias,someBcellmalignancies;dendriticcellsinmostperipheralcutaneousTcelllymphomas, AJCP2001;116:
72
Negativestaining:
normalBcells,mostcutaneousperipheralBcelllymphomas(?
reflectsreplacementofreactivepatterncontainingdendriticcellswithaneoplasticpatternofBcells)
Microimages:
Langerhanscellhistiocytosis
Microimages(AJSPsubscribers):
pulmonaryLangerhanscellhistiocytosis
Microimages(HumPathsubscribers):
Langerhanscellhistiocytosis
References:
AJSP2001;25:
630
CD1b
Positivestaining(disease):
myeloidleukemiasandsomeBcellmalignancies
Negativestaining:
normalBcells
CD1c
Positivestaining(normal):
subsetofnormalperipheralBcells
Positivestaining(disease):
myeloidleukemiasandsomeBcellmalignancies
Negativestaining:
normalBcells
CD1d
Positivestaining(normal):
thymus(lowlevels),bowel
CD1e
CD2
AkaErosettereceptor,LFA-2(leukocytefunctionantigen)
Function:
bindsCD58/LFA-3onantigen-presentingcells,andinducescostimulatorysignalsinTcells
AlsoregulatesTandNK-mediatedcytolysis,inhibitsapoptosisofactivatedperipheralTcells,mediatesTcellcytokineproduction,regulatesTcellanergy
Positivestaining(normal):
thymocytes(95%),matureperipheralTcells(almostall),NKcells(80-90%),thymicBcells(50%)
Microimages:
extranodalNK/Tcelllymphoma,nasaltype
CD2R
CD2epiesrestrictedtoactivatedTcells
Positivestaining:
activatedTcells,?
NKcells
CD3
AkaOKT3
Function:
complex(5chains)ofintegralmembraneglycoproteinsassembledasacomplex;haslongcylasmictailwithantigenrecognitionactivationmotif;complexisthendownregulated
Alsosubdividedintodelta,epsilon,gammasubtypes
CylasmicexpressionatearlyTcelldifferentiation,thenmembranousexpression
MostspecificTcellantibody
Positivestaining(normal):
thymocytes,peripheralTcells,NKcells;alsoPurkinjecellsofcerebellum
Positivestaining(disease):
80%ofTcelllymphomas
Negativestaining:
gammadeltaTcellreceptors,mostBcelllymphomas
Microimages:
CD3epsilon-testicularNK/Tcelllymphoma(figure3D)
Microimages(AJSPsubscribers):
achalasia,post-transplantlymphoproliferativediseaseinliver
References:
AJSP2001;25:
1413
CD4
AkaOKT4,Thelper/inducer
Onchromosome#12p
Nonpolymorphousglycoproteinsbelongingtoimmunoglobulinsuperfamily
ServesasHIVreceptoronTcells(asdochemokinereceptorsCCR5andCXCR4),macrophages,brain
CD4+TcellsarekilledbyHIV
CoreceptorinMHCclassII-restrictedantigeninducedTcellactivation
BindstononpolymorphicregionofclassImolecules;mayincreaseavidityofcell-cellinteractions
Positivestaining(normal):
thymocytes(80-90%),matureTcells(65%,ThelperandCD4/CD8+thymocytes),macrophages,Langerhanscells,dendriticcells,granulocytes
Positivestaining(disease):
pityriasislichenoides
Microimages:
acutedemyelinatingdisease,extranodalNK/Tcelllymphoma,nasaltype
CD5
Belongstoancientscavengerreceptorfamily
IsphysicallyandfunctionallycoupledwithTcellreceptor-zeta-CD3signaltransducercomplex
CD5+Bcellsproduce“generalistantibodies”-polyreactivelowaffinity“natural”antibodiestoexogenousantigens(tetanustoxoid,lipopolysaccharide)aswellasautoreactiveantibodies(ssDNA,thyroglobulin,insulin)
Note:
sharksonlyhavepolyreactiveIgM
Note:
monoreactiveIgGisproducedby<0.1%ofcirculatingBcells,frompositiveselectionandsomatic
pointmutation
Firstlineofdefenseagainstantigens;havealowactivationthreshold;aretheonlylineofdefenseforthosewhocannotproducespecificantibody
Produceantibodiesusinggermline(nonmutated)configurationofgenesegments,usuallyIgM
Productionelevatedinrheumatoidarthritis(27-52%ofcirculatingBcellsvs.20%normal)
CD5mayserveasadualreceptor,givingeitherstimulatoryorinhibitorysignalsdependingbothonthecelltypeandthedevelopmentstage
Positivestaining(normal):
Bcellsofmantlezoneofspleenandlymphnodes;Bcellsinperitonealandpleuralcavities;almostallTcells;
Infetus,mostBcellsinspleenandcordbloodareCD5positive
Positivestaining(disease):
BcellCLL/SLL,mantlecelllymphoma,mostTmalignancies,thymiccarcinomas(70%)
Negativestaining:
spindlecellthymomas,MALTlymphoma,follicularlymphoma
Microimages:
extranodalNK/Tcelllymphoma,nasaltype,mantlecelllymphoma(figure3D)
CD6
Adhesionmoleculemediatingthebindingofdevelopingthymocyteswiththymicepithelialcells
Maybeinvolvedinautoimmunityandgraftvs.hostdisease(GVHD)
AntibodiestoCD6areusedtodepleteTcellsfrombonemarrowtransplantstopreventGVHD
Positivestaining(normal):
lowlevelsonimmaturethymocytes,highlevelsonmaturethymocytes
CD7
MembraneglycoproteinandFcreceptorforIgM
HomologoustoTCRgamma,Igkappa
MembraneexpressionearlyduringTontogeny,beforeTCRrearrangement,persistsuntilterminalstagesofTcelldevelopment
LowerexpressioninmemoryTcellsvs.naiveTcells
Positivestaining(normal):
matureperipheralTcells(85%),post-thymicTcells(majority),NKcells(majority),somemyeloidcells
Positivestaining(disease):
TcellALL;AML(especiallyM4/M5),chronicmyelogenousleukemia,blastsintransientmyeloproliferativedisorder
Negativeexpression:
BcellALL,Sezarysyndrome,adultTcellleukemia/lymphoma
Microimages:
extranodalNK/Tcelllymphoma,nasaltype
CD8
AkaOKT8,Tcellsuppressor/cytotoxiccells
Onchromosome#2
MHCclassIrestrictedreceptor;bindstononpolymorphicregionofclassImolecules;mayincreaseavidityofcell-cellinteractions
Associatedwithlymphoepithelioma-likecarcinomaoflung(AJSP2002;26:
715)
Positivestaining(normal):
Tcells(25-35%ofmatureperipheralTcells,mostcytotoxicTcells,CD4/CD8+thymocytes);NKcells(30%-whicharealsoCD3negative);corticalthymocytes(70-80%),epidermotrophiclymphocytesinmycosisfungoides(AJSP2002;26:
450)
Microimages:
lymphoepithelioma-likecarcinomaofcervix-figure3,acutedemyelinatingdisease
Microimages(ModPathsubscribers):
nodalcytotoxicTcelllymphoma
Reference:
ModPath2002;15:
1131
CD9
Maymediateplateletactivationandaggregation
Antibodiesareusedtopurgebonemarrowpriortoperipheralstemcellbonemarrowtransplant
Viralco-receptor
Positivestaining(normal):
preBcells,Bcellsubset,Tcells,macrophages,platelets,eosinophils,basophils,megakaryocytes,endothelialcells,brain,peripheralnerve,vascularsmoothmuscle,cardiacmuscle,epithelia
CD10
Aka Common Acute Lymphoblastic Leukemia Antigen(CALLA),neutralendopeptidase24.11,neprilysin,enkephalinase
Cellmembranemetallopeptidase,characteristicmarkeroffollicularcentercellsandfollicularlymphoma,butalsowidelydistributedinnormaltissueandneoplasms;alsolocalizedtobrushborderinsmallbowelmucosa
Inactivatesbioactivepeptides
Uses:
Acutelymphoblasticleukemia:
oneoffirstmarkerstoidentifyleukemiccellsinchildren(henceitsname)
Breast:
markerofmyoepithelialcells, ModPath2002;15:
397
Burkittlymphoma:
confirmdiagnosis
Coloniccarcinogenesis:
increasein
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- DNA 实验 免疫 细胞 表面抗原 分子 CD 家族 对照 CD1CD24