山东大学生化考试英文内部资料.docx
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山东大学生化考试英文内部资料.docx
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山东大学生化考试英文内部资料
山东大学医学院
(2008——2009学年第1学期)
2007级医、药、卫、口、护专业生物化学试题(A卷)
BiochemistryExaminationPaperforInternationalStudents
Grade2007
题号
一
二
三
四
五
六
七
八
九
十
总分
统分人
得分
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评卷人
Ⅰ.Explainthefollowingterms(30marks,6marks/each)
1.Motif:
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2.Activecenterofenzyme:
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3.Oxidativephosphorylation:
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4.Onecarbonunit:
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5.Biotransformation:
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Ⅱ.Choice:
(30marks,1mark/each)
Singlechoice:
Choosetheonebestanswer(18marks,1mark/each)
1.Whichofthefollowingaminoacidsisiminoacid
A.prolineB.histidine
C.glycineD.tryptophan
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E.lysine
2.Whichofthefollowingaminoacidsissulfur-containingaminoacid
A.TrpB.Thr
C.PheD.Met
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E.Pro
3.Proteinconformationisdeterminedby
A.α-helixandβ-pleatedsheet
B.ionicbond/saltbondinpeptidechain
C.sequenceofaminoacidinpeptidechain
D.disulfidebondinpeptidechain
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E.hydrogenbondinpeptidechain
4.Whichofthefollowingchemicalbondsisinvolvedinmaintainingα-helix
andβ-
pleatedsheet
A.peptidebondB.ionicbond/saltbond
C.disulfidebondD.hydrophobicbond
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E.hydrogenbond
5.Whichofthefollowingdescriptionsaboutdenaturationofhemoglobiniscorrect
A.Thespatialstructureisdestroyedandbiologicalactivityislost
B.TheprimarystructureandbiologicalactivityofHbarenotchanged
C.Peptidebondsarecleavedandbiologicalactivityofproteinislost
D.Thespatialstructureandbiologicalactivityarenotchanged
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E.Theprimarystructureischangedandbiological
activityislost
6.Whichofthefollowingtechniquesusedforproteinseparationisonlybasedonmolecularweight(MW)ofprotein
A.anion-exchangechromatography
B.cation-exchangechromatography
C.gelfiltration
D.affinitychromatography
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E.electrophoresis
7.1molglucoseisconvertedintoCO2andH2O.HowmanyATPsareproduced?
A.8B.10C.38
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D.32E.2
8.Theimportantendproductsofpentosephosphatepathwayare:
A.5-phosphateribose,NADH
B.6-phosphateglucose,NADPH
C.5-phosphateribose,NADPH
D.6-phosphatefructose,NADPH
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E.5-phosphateribose,FADH2
9.Theactiveformofglucoseinglycogensynthesisis:
A.glucoseB.G-6-PC.G-1-P
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D.UDPGE.CDPG
10.ThecarrierforlongchainacylCoAtoenterintomitochondriais:
A.CitricacidB.Malicacid
C.3-glycerophosphateD.Carnitine
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E.ACP
11.Whichoneofthefollowingprocessesmainlyoccursinmitochondria:
A.FattyacidsynthesisB.Cholesterolsynthesis
C.PhospholipidsynthesisD.HydrolysisofTG
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E.β-oxidationoffattyacid
12.LipoproteinthatcarriesdietaryTGis:
A.VLDLB.LDL
C.HDLD.IDL
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E.CM
13.ThecorrectdelineationaboutCOQis:
A.isthecompositionofenzymecomplexⅠandenzymecomplexⅡ
B.istheelectroniccarrieronly
C.candiffusefastinmitochondrialinnermembrane
D.watersolubility
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E.cantransferelectrontoFeS
14.Whichpositionofelectrontransferchainisblockedbycyanideoriginatedtoxication.
A.Cytaa3→O2B.Cytb→c1
C.Cytc1→cD.Cytc→aa3
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E.CoQ→Cytb
15.Themajorstoragepatternofhighenergyphosphatebondsinmuscleis:
A.ATPB.GTP
C.phosphocreatineD.CTP
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E.UTP
16.Aboutthedonerofactivemethylgroupinbody,whichoneiscorrect?
A.N5–CH3–FH4
B.methionine
C.S-adenosylhomocysteine
D.N10–CH3–FH4
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E.S-adenosylmethionine
17.Themainmechanismofammoniametabolisminliveris:
A.Synthesizeaminoacid
B.Synthesizeglutamine
C.Synthesizeurea
D.Synthesizeprotein
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E.Synthesizepurine
18.Whichoneofthefollowingcanbindwithunconjugatedbilirubinandformconjugatedbilirubin?
A.Glucuronicacid
B.Globulin
C.Z-protein
D.Y-protein
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E.Albumin
Multiplechoice:
Chooseanycorrectanswer(12marks,1mark/each)
19.Whichofthefollowingdescriptionsaboutpeptideunitiscorrect
A.thebasicunitformingthesecondarystructureofpolypeptidechain
B.6atomsthatformpeptidebondareinthesameplane
C.bondlengthofpeptidebondisbetweensinglebondanddoublebond
D.thesinglebondthatconnectstoα-carbonatomcanfreelyrotate
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E.thepositionoftwoneighborpeptideunitsisrelatedtothepositionofpeptidebonds
20.Whichoffollowingdescriptionsabouthemoglobin(Hb)iscorrect
A.OxygendissociationcurveofhemoglobinisS-type
B.PorphyrinFe2+isconvertedtoporphyrinFe3+when
HbbindstoO2
C.Thereisnotcooperative
effectwhensubunitofHbcombinewithO2
D.TensestateofHbisgraduallyconvertedtoitsrelaxedstatewhensubunitsofHbbindtoO2
onebyone
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E.Thereare6pairsofsaltbondsbetweensubunitsofHb
21.whichofthefollowingarefunctionofprotein
A.tostoregeneticinformation
B.toregulatesubstancemetabolism
C.totransportsubstance
D.toparticipateinloodclotting
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E.toparticipateintransferringgeneticinformation
22.Thesecondarystructureofproteinincludes
A.α-helixB.β-pleatedsheet
C.β-turnD.randomcoil
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E.domain
23.Bloodlipidsinclude:
A.TGB.Cholesterol
C.PhospholipidD.Freefattyacid
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E.Ketonebodies
24.Triacylglycerolsintheserumaretransportedby:
A.HDL.
B.VLDL.
C.LDL.
D.CM.
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E.Noneoftheabove.
25.Theendproductoftricarboxylicacidcycleis:
A.pyruvateB.lactate
C.CO2D.NADH
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E.FADH2
26.Whichreactionistheirreversiblereactioninglycolysis?
A.pyruvate→lactate
B.fructose-1,6-bisphosphate→glyceraldehyde-3-phosphate
+dihydroxyacetone
C.glucose→glucose-6-phosphate
D.fructose-6-phosphate→fructose-1,6-bisphosphate
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E.phosphoenolpyruvate→pyruvate
27.Thecorrectdescriptionaboutshuttleis
A.NADHcannotpassthroughmitochondrialmembranefreely
B.whentwohydrogenentercytomicrosomebyα-glycerolphosphateshuttlemechanismtobeoxidized,1.5ATPareformed
C.whentwohydrogenentercytomicrosomebymalate/aspartateshuttlemechanismtobeoxidized,2.5ATPareformed
D.Thereasonofα-glycerolphosphateshuttlelessobtainoneATPisthattheprocessneedtoconsumeenergy
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E.FADH2createdinthecytoplasmcanbeshuttledintothemitochondria
28.ThecharacterofATPinenergymetabolismisthat
A.Itschemicalenergycanturntoosmoticenergyandelectricenergy
B.ATPproductionisformedinoxidativephosphorylationmainly
C.ATPisthecenterofenergyproduction,storage,utilization
D.TheenergythatneededinvivosynthesisreactioncanbedirectlysuppliedbyATPonly
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E.Theprocessesofnutrientsmetabolismareused
mainlytoproduceATP
29.Themajorformsfortransporttoxicammoniabetweentissuesandliverinclude
A.glutamineB.asparagine
C.ureaD.alanine
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E.onithine
30.whichoneiscorrectaboutthestatementofconjugatedbilirubin?
A.Water-soluble
B.Canexcretefromurine
C.Smalltoxicity
D.CanreactwithDiazoreagentdirectly
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E.Conjugatewithalbumin
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统分人
Ⅲ。
Answerthefollowingquestions(40marks)
得分
1、Pleasedescribethefactorsthataffecttherateofenzyme-catalyzedreactionsbriefly.(6marks)
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评卷人
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2、Whystoredmuscleglycogencan’tbebrokendowntoglucosedirectly?
Underheavyactivity,muscleglycogencanbeconvertedintoglucoseindirectlyvialactatecycle(Coricycle).Howcouldthisprocesshappen?
Pleasewritedownthemainprocessesandenzymes.(10marks)
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3、HowcouldthefattyacidsbeoxidizedtoformCO2,H2OandATP?
(Writethekeyreactionsandenzymes)(12marks)
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4、Explainthemechanismofhyperammonemiacausedbyliverdysfunctionandtoxicityofammonia.(6marks)
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评卷人
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5.Pleasedescribethemetabolicprocessofbilirubinintheliver.Whenliverfunctionisdestroyed,whathappenedwithserumbilirubinlevel?
Why?
(6marks)
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评卷人
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