最新中国和全球肿瘤发病率和死亡率解析.pptx
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最新中国和全球肿瘤发病率和死亡率解析.pptx
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最新肿瘤发病率和死亡率解析,中国&全球,-2012中国肿瘤登记年报-GlobalCancerStatistics2011byIARC,TangJian2013/3/12,中国肿瘤发病率和死亡率总体情况中国肿瘤发病率和死亡率(按性别)中国肿瘤发病率和死亡率(按地域)中国肿瘤发病率和死亡率(按年龄)中国排名前十肿瘤病种的发病率和死亡率全球肿瘤发病率和死亡率具体情况,目录CONTENTS,中国肿瘤发病率和死亡率总体情况,总体肿瘤发病率和死亡率较高:
肿瘤发病率:
每10万人中有286人患癌;一生中有22%的概率患癌症。
肿瘤死亡率:
每10万人有181人患癌死亡;一生中有13%的概率患癌死亡;每分钟就有6人被确诊为癌症,平均每5位癌症患者有3人死亡。
中国肿瘤发病率和死亡率(按性别),相比女性,男性癌症发病率和死亡率都高:
肿瘤发病率:
男女之比1.3:
1;肿瘤死亡率:
男女之比1.65:
1。
一生中,男性患癌症概率为26%,女性19%一生中,男性因患癌死亡概率为17%,女性为9%患癌人群中,因患癌而死亡的概率,男性(71%)比女性(54%)高,中国肿瘤发病率和死亡率(按地域),城市人口与农村人口相比,癌症发病率要略高,但一生中因患癌症死亡率要低:
肿瘤发病率:
城市与农村之比1.2:
1;肿瘤死亡率:
城市与农村之比1.02:
1。
一生中,城市患癌症概率为22.23%,农村21.76%。
一生中,城市患癌死亡概率为12%,农村为15%。
患癌人群中,因患癌而死亡的概率,城市人口(60%)比农村人口(71%)低,中国肿瘤发病率和死亡率(按年龄),肿瘤发病率随人群年龄逐渐上升,特别是50岁以上随年龄增加而大幅上升50岁以上占全部发病的80%以上;80-85岁最高。
中国肿瘤发病率和死亡率(按年龄),肿瘤死亡率随人群年龄逐渐上升,特别是60岁以上随年龄增加而大幅上升60岁以上约占全部死亡的63%以上;85岁以上达到最高。
中国排名前十肿瘤病种的发病率和死亡率(总体情况),发病率与死亡率最高的均是肺癌,排名前十病种的发病率占比76.39%。
排名前十病种的死亡率占比84.27%.,中国排名前十肿瘤病种的发病率(按性别),男性发病率最高的是肺癌,其次为胃癌、肝癌。
排名前十病种的发病率占比84.14%。
女性发病率最高的是乳腺癌,其次为肺癌、结直肠癌。
排名前十病种的发病率占比77.57%。
中国排名前十肿瘤病种的死亡率(按性别),男性死亡率最高的是肺癌,其次为肝癌、胃癌。
排名前十病种的死亡率占比88.33%。
女性死亡率最高的是肺癌,其次为胃癌、肝癌。
排名前十病种的死亡率占比81.12%。
全球肿瘤发病率和死亡率具体情况,Worldwide,1.1:
1,1.26:
1,Total:
12,700,000,Total:
7,600,000,Developedcountries,Developingcountries,Itshouldalsobenotedthatcancertendstobediagnosedatlaterstagesinmanydevelopingcountriescomparedwithdevelopedcountriesandthis,combinedwithreducedaccesstoappropriatetherapeuticfacilitiesanddrugs(Fig.3),hasanadverseeffectonsurvival.,SelectedCancersFemaleBreastCancer,1,Breastcanceristhemostfrequentlydiagnosedcancerandtheleadingcauseofcancerdeathinfemalesworldwide,accountingfor23%(1.38million)ofthetotalnewcancercasesand14%(458,400)ofthetotalcancerdeathsin2008(Fig.2),Abouthalfthebreastcancercasesand60%ofthedeathsareestimatedtooccurineconomicallydevelopingcountries.,Ingeneral,incidenceratesarehighinWesternandNorthernEurope,Australia/NewZealand,andNorthAmerica;intermediateinSouthAmerica,theCaribbean,andNorthernAfrica;andlowinsub-SaharanAfricaandAsia.,Thefactorsthatcontributetotheinternationalvariationinincidencerateslargelystemfromdifferencesinreproductiveandhormonalfactorsandtheavailabilityofearlydetectionservices.,Reproductivefactorsthatincreaserisk,1,2,3,4,5,longmenstrualhistory,oralcontraceptives,lateageatfirstbirth,nulliparity,recentuseofpostmenopausalhormonetherapy,Howtoreducetheriskofdevelopingbreastcancer?
MaintainingahealthybodyweightIncreasingphysicalactivityMinimizingalcoholintakeEarlydetectionstrategiesincludethepromotionofawarenessofearlysignsandsymptomsandscreeningbyclinicalbreastexamination,SelectedCancersColorectalCancer,2,Colorectalcanceristhe3rdmostcommonlydiagnosedcancerinmalesandthe2ndinfemales,withover1.2millionnewcancercasesand608,700deathsestimatedtohaveoccurredin2008.,ThehighestincidenceratesarefoundinAustraliaandNewZealand,Europe,andNorthAmerica,whereasthelowestratesarefoundinAfricaandSouth-CentralAsia.Ratesaresubstantiallyhigherinmalesthaninfemales.,TrendsRiskFactors,Ratescontinuetoincreaseincountrieswithlimitedresourcesandhealthinfrastructure,particularlyinEasternEuropeandEasternAsia,WhiledecreasinginseveralWesterncountries,particularlyinUnitedStates,Canada,andAustralia,SmokingPhysicalinactivityOverweight/ObesityRedandprocessedmeatconsumptionExcessivealcoholconsumptionPopulation-basedcolorectalscreeningprograms*,*AccordingtoarecentrandomizedtrialintheUnitedKingdom,aone-timeflexiblesigmoidoscopyscreeningbetween55and64yearsofagereducedcolorectalcancerincidenceby33%andmortalityby43%.,SelectedCancersLungCancer,3,Lungcancerwasthemostcommonlydiagnosedcanceraswellastheleadingcauseofcancerdeathinmalesin2008globally.Amongfemales,itwasthe4thmostcommonlydiagnosedcancerandthe2ndleadingcauseofcancerdeath.Lungcanceraccountsfor13%(1.6million)ofthetotalcasesand18%(1.4million)ofthedeathsin2008.,Inmales,thehighestlungcancerincidenceratesareinEasternandSouthernEurope,NorthAmerica,andEasternAsia,whileratesarelowinsub-SaharanAfrica.Infemales,thehighestlungcancerincidenceratesarefoundinNorthAmerica,NorthernEurope,andAustralia/NewZealand.,Smokingaccountsfor80%oftheworldwidelungcancerburdeninmalesandatleast50%oftheburdeninfemales.,MalelungcancerdeathratesaredecreasinginmostWesterncountries,includingmanyEuropeancountries,NorthAmerica,andAustralia,wherethetobaccoepidemicpeakedbythemiddleofthelastcentury.Incontrast,lungcancerratesareincreasingincountriessuchasChinaandseveralothercountriesinAsiaandAfrica,wheretheepidemichasbeenestablishedmorerecentlyandsmokingprevalencecontinuestoeitherincreaseorshowsignsofstability.,byapplyingproventobaccocontrolinterventionsthatincluderaisingthepriceofcigarettes*andothertobaccoproducts,banningsmokinginpublicplaces,therestrictionofadvertisingoftobaccoproducts,counteradvertising,andtreatingtobaccodependence.,avoidtheburdenoflungcancer,Beststrategy,*a10%increaseincigarettepriceshasbeenshowntoreducecigaretteconsumptionby3%to5%.,SelectedCancersProstateCancer,4,Prostatecanceristhe2ndmostfrequentlydiagnosedcancerandthe6thleadingcauseofcancerdeathinmales,accountingfor14%(903,500)ofthetotalnewcancercasesand6%(258,400)ofthetotalcancerdeathsinmalesin2008。
Incidenceratesvarybymorethan25-foldworldwidelargelybecauseofthewideutilizationofprostate-specificantigen(PSA)testing.Deathratesforprostatecancerhavebeendecreasinginmanydevelopedcountries,includingAustralia,Canada,theUnitedKingdom,theUnitedStates,Italyinpartbecauseoftheimprovedtreatmentwithcurativeintent.,theonlywell-establishedriskfactors,Olderage,Race(black),Familyhistory,therearenoestablishedpreventableriskfactorsforprostatecancer.,SelectedCancersStomachCancer,5,Atotalof989,600newstomachcancercasesand738,000deathsareestimatedtohaveoccurredin2008,accountingfor8%ofthetotalcasesand10%oftotaldeaths.Over70%ofnewcasesanddeathsoccurindevelopingcountries.Generally,stomachcancerratesareabouttwiceashighinmalesasinfemales.,ThehighestincidenceratesareinEasternAsia,EasternEurope,andSouthAmericaandthelowestratesareinNorthAmericaandmostpartsofAfrica.Regionalvariationsinpartreflectdifferencesindietarypatterns,particularlyinEuropeancountries,andtheprevalenceofHelicobacterpyloriinfection.,1,2,3,4,theincreaseduseandavailabilityofrefrigerationincludingtheincreasedavailabilityoffreshfruitsandvegetables,andadecreasedrelianceonsaltedandpreservedfoods.,Rateshavedecreaseddueto(westerncountries):
reductionsinchronicH.pyloriinfectioninmostpartsoftheworld.,reductionsinsmokinginsomepartsofthedevelopedworld.,InJapan,mortalityratesmayhavedeclinedviatheintroductionofscreeningusingphotofluorography.,SelectedCancersLiverCancer,6,Livercancerinmenisthe5thmostfrequentlydiagnosedcancerworldwidebutthe2ndmostfrequentcauseofcancerdeath.Inwomen,itisthe7thmostcommonlydiagnosedcancerandthe6thleadingcauseofcancerdeath.Anestimated748,300newlivercancercasesand695,900cancerdeathsoccurredworldwidein2008.,HalfofthesecasesanddeathswereestimatedtooccurinChina.Globally,ratesaremorethantwiceashighinmalesasinfemales.,Riskfactorsaccountingforlivercancer,1,2,3,4,5,chronicHBV/HCVinfection,nonalcoholicfattyliverdisease,obesity,alcohol-relatedcirrhosis,aflatoxinB1(AFB)exposure,LivercancerincidenceratesareincreasinginmanypartsoftheworldincludingtheUnitedStatesandCentralEurope,possiblyduetotheobesityepidemicandtheriseinHCVinfectionthroughcontinuedtransmissionbyinjectiondrugusers.Incontrasttothetrendinthelow-riskareas,ratesdecreasedinsomehistoricallyhigh-riskareas,possiblyduetotheHBVvaccine.UniversalinfanthepatitisvaccinationprogramsinTaiwanreducedlivercancerincidenceratesbyabouttwo-thirdsinchildrenandyoungadults.,introducedtheHBVvaccineintotheirnationalinfantimmunizationschedules(Fig.10).PreventivestrategiesagainstHCV,includescreeningofdonorsbloodforantibodiestoHCV,institutingadequateinfectioncontrolpracticesincludingtheuseoforaldeliveryofmedicineswherepossible,andneedleexchangeprogramsamonginjectiondrugusers.CropsubstitutionandimprovedgrainstoragepracticeshavebeenshowntoreducecontaminationwithAFB.,avoidtheburdenoflivercancer,Beststrategy,SelectedCancersCervicalCancer,7,Cervicalcanceristhe3rdmostcommonlydiagnosedcancerandthe4thleadingcauseofcancerdeathinfemalesworldwide,accountingfor9%(529,800)ofthetotalnewcancercasesand8%(275,100)ofthetotalcancerdeathsamongfemalesin2008.Morethan85%ofthesecasesanddeathsoccurindevelopingcountries.India,the2ndmostpopulouscountryintheworld,accountsfor27%(77,100)ofthetotalcervicalcancerdeaths.,Worldwide,thehighestincidenceratesareinEastern,Western,andSouthernAfrica,aswellasSouth-CentralAsiaandSouthAmerica.RatesarelowestinWesternAsia,Australia/NewZealand,andNorthAmerica.Thedisproportionatelyhighburdenofcervicalcancerindevelopingcountriesandelsewhereinmedicallyunderservedpopulationsislargelyduetoalackofscreeningthatallowsdetectionofprecancerousandearlystagecervicalcancer.,Themostefficientandcost-effectivescreeningtechniquesinlow-resourcecountries,visualInspectionaceticacid/Lugolsiodine,HPVDNAtesting,ArecentclinicaltrialinruralIndia,alow-resourcearea,foundthatasingleroundof
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