生物发酵产品目前能达到的水平参考大全doc.docx
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生物发酵产品目前能达到的水平参考大全doc.docx
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生物发酵产品目前能达到的水平参考大全doc
2019年生物发酵产品目前能达到的水平参考大全.doc
D
Vancomycin FinalTitre:
9-10g/L
FermentationTime:
150hrs
Recovery:
>70%
替考拉宁
TeicoplaninFinalTitre:
4-5g/L
FermentationTime:
150hrs
Recovery:
>70%
达托霉素
Daptomycin FinalTitre2.0g/L
FermentationTime:
200hrs
Recovery:
>40%Orcubicin
莫匹罗星
Mupirocin FinalTitre:
4-5g/L
FermentationTime:
60-70hrs
Recovery:
>75%
PneumocandinB0FinalTitre:
1.7g/L
FermentationTime:
11-12days
Recovery:
>60%Caspofungin
雷莫拉宁
RamoplaninFinalTitre:
3g/L
FermentationTime:
200hrs
Recovery:
>60%
普那霉素(原始霉素)
PristinamycinFinalTitre:
8/L
FermentationTime:
150hrs
Recovery:
>70%
克拉维酸(棒酸)
ClavulanicacidFinalTitre:
6g/L
FermentationTime:
105hrs
Recovery:
55%
头孢菌素C
CephalosporinCFinalTitre:
40g/L
FermentationTime:
168hrs
Recovery:
80%各种头孢类中间体
青霉素G
PenicillinGFinalTitre:
120000g/L
FermentationTime:
220hrs
Recovery:
80%
红霉素
Erythromycin FinalTitre:
9-10g/L
FermentationTime:
156hrs
Recovery:
60%依托红霉素、琥乙红霉素、地红霉素、罗红霉素、阿奇霉素和克拉霉素的中间体
去甲金霉素
Demethylchlortetracycline(DMCT)FinalTitre:
16g/L
FermentationTime:
200hrs
Recovery:
75%Intermediatefor
Minocycline,
Tigecylcine
林可霉素(洁霉素)
LincomycinFinalTitre:
9-10g/L
FermentationTime:
200hrs
Recovery:
80-90%克林霉素中间体
Clindamycin
杆菌肽
BacitracinFinalTitre:
1200U/ml
FermentationTime:
50-60hrs
Recovery:
95%ZincBacitracinfor
Animalfeedadditive
那西肽
NosiheptideFinalTitre:
1700-2000U/ml
FermentationTime:
50hrs
Recovery:
95%Animalfeedadditive
两性霉素B
AmphotericinBFinalTitre:
10000U/ml
FermentationTime:
130-140hrs
Recovery:
75%
阿维拉霉素(卑霉素)
Avilamycin FinalTitre:
7-8g/L
FermentationTime:
268hrs
Recovery:
95%Animalfeedadditive
恩拉霉素
Enramycin FinalTitre:
8-10g/L
FermentationTime:
260hrs
Recovery:
95%Animalfeedadditive
卡那霉素
Kanamycin FinalTitre:
25g/L
FermentationTime:
240hrs
Recovery:
85%
卷曲霉素
CapreomycinFinalTitre:
11000U/ml
FermentationTime:
150-160hrs
Recovery:
75%
庆大霉素C
GentamicinCFinalTitre:
5-6g/L
FermentationTime:
14days
Recovery:
75%
庆大霉素B
GentamycinBFinalTitre:
1000Mmg/L
FermentationTime:
120-130hrs
Recovery:
75%异帕米星
(Isepamicin)
多粘菌素B
PolymyxinBFinaltitre2.5g/l
Fermentationtime72hrs
Recoveryyield70%
粘杆菌素E
PolymyxinE Finaltitre600000U/ml
Fermentationtime96hrs
Recoveryyield75%
泰乐菌素
Tylosin Finaltitre15000U/l
Fermentationtime180hrs
Recoveryyield70%
巴龙霉素
Paromomycin Finaltitre8g/l
Fermentationtime170hrs
Recoveryyield70%
制霉菌素
Nystatin Finaltitre300,000IU/ml
Fermentationtime280hrs
Recoveryyield85%
盐霉素
Salinomycin Finaltitre80g/l
Fermentationtime268hrs
Recoveryyield90%
金霉素
Chlortetracycline Finaltitre50g/l
Fermentationtime200hrs
Recoveryyield90%
四环素
TetracyclineFinaltitre40g/l
Fermentationtime200hrs
Recoveryyield90%
土霉素
OxytetracyclineFinaltitre40g/l
Fermentationtime200hrs
Recoveryyield90%
链霉素
StreptomycinFinaltitre28,000U/ml
Fermentationtime200hrs
Recoveryyield80%
利福霉素
Rifamycin
Finaltitre30g/l
Fermentationtime220hrs
Recoveryyield75%
黄霉素
Flavomycin Finaltitre8g/l
Fermentationtime168hrs
Recoveryyield90%
截短侧耳素
Pleuromutilin Finaltitre14000U/ml
Fermentationtime300hrs
Recoveryyield80%泰妙菌素
Tiamulin
大观霉素
SpectinomycinFinaltitre7000-10000U/ml
Fermentationtime130-150hrs
Recoveryyield70%
莫能菌素
Monensin38000u/ml
Finaltitre6500-8000U/ml
Fermentationtime140-170hrs
Recoveryyield70-80%
妥布霉素
TobramycinFinaltitre6500-8000U/ml
Fermentationtime140-170hrs
Recoveryyield70-80%
安普霉素
ApramycinFinaltitre6500-8000U/ml
Fermentationtime140-170hrs
Recoveryyield70-80%
尼可霉素
NikkomycinFinaltitre7-8g/l
Fermentationtime70hrs
Recoveryyield80%
麦角酸
LysergicacidFinaltitre7-8g/l
Fermentationtime360hrs
Recoveryyield70%Forcabergolineandnicergoline
夫西地酸
FusidicAcid Finaltitre4-5g/l
Fermentationtime200hrs
Recoveryyield40%
麦迪霉素
Medimycin
Finaltitre18g/l
Fermentationtime200hrs
Recoveryyield75%
莫能菌素
MonensinFinalTitre:
40000U/ml
FermentationTime:
300hrs
Recovery:
95%
马杜霉素
MaduramicinFinalTitre:
612000U/ml
FermentationTime:
200hrs
Recovery:
95%
利福霉素
RIFAMYCIN FinalTitre:
25g/L
FermentationTime:
240hrs
Recovery:
80%
磷霉素
Fosfomycin
氯霉素
Chloramphenicol
灰黄霉素
Griseofulvin
螺旋霉素
Spiramycin//RovamycinFinalTitre:
6000U/ml
FermentationTime:
160hrs
Recovery:
75%
小诺霉素
Micronomicin
维吉尼亚霉素
Virginmycin R&D
亮菌甲素(假蜜环菌素)Armillarisina.
美贝霉素
MilbemycinSeeking
莫西菌素
Moxidectin
道拉菌素
Doramectin
土拉霉素
TulathromvcinSeeking
米卡芬净
micafunginR&D
阿尼芬净
anidulafunginR&D
Bio-PESTICIDE
阿维菌素
Abamectin
FinalTitre:
4.5g/l
Flask:
4.8-5.0g/L
Time:
240hrs
Recovery:
80%Including
itsderivatives
多杀菌素
Spinosad FinalTitre:
12g/L
FermentationTime:
200-240hrs
Recovery:
80%
Bio-pesticide
井冈霉素
Validamycin FinalTitre:
3-4g/L
FermentationTime:
60-70hrs
Recovery:
80%
春雷霉素
KasugamycinFinalTitre:
8000-1000U/ml
FermentationTime:
192hrs
Recovery80%
多抗霉素
PolyoxinFinalTitre:
5000U/ml
FermentationTime:
192hrs
Recovery:
80%
脱落酸
AbscisicAcid(ABA) FinalTitre:
1.6g/L
FermentationTime:
70-72hrs
Recovery:
60-65%Planthormone
Biopesticide
赤霉素
Gibberellin(GA3)FinalTitre:
2.5-2.8g/L
FermentationTime:
150-160hrs
Recovery:
80%
中生霉素
zhongshengmycinFinalTitre:
10g/L
FermentationTime:
1200hrs
Recovery:
80%
枯草芽孢杆菌
BacillussubtilisFinalTitre6000U/ml
FermentationTime:
150-160hrs
Recovery:
80%
苏云金杆菌
BacillusthuringiensisFinalTitre:
5500g/ml
FermentationTime:
150-160hrs
Recovery:
80%
浏阳霉素
Liuyangmycin
宁南霉素
Ningnanmycin
链霉素
streptomycin
Foragriculture
ANTI-DIABETES
米格列醇
Miglitol FinalTitre:
2g/L
FermentationTime:
70-72hrs
Recovery:
60-65%
Synthesis:
90%
阿卡波糖
Acarbose FinalTitre:
5-6g/L
FermentationT,ime:
130-150hrs
Recovery:
30-40%
伏格列波糖
VegliboseChemicalsynthesis
ANTI-TUMOR
柔红霉素
Daunomycin FinalTitre:
1.5g/L
FermentationTime:
168hrs
Recovery:
>67%Forepirubicin,
Idarubicin, doxorubicin
洋红霉素
CarminomycinFinaltitre0.15g/l
Fermentationtime168hrs
Recoveryyield65%
偏端霉素
Distamycin Finaltitre2g/l
Fermentationtime120hrs
Recoveryyield52%
博莱霉素
BleomycinFinaltitre4g/l
Fermentationtime168hrs
Recoveryyield70%
紫杉醇
Paclitaxel Finaltitre200mg/l
Fermentationtime120hrs
Recoveryyield50%
丝裂霉素C
MitomycinCFinaltitre1000mg/l
Fermentationtime200hrs
Recoveryyield50%
阿霉素
DoxorubicinChemicalsynthesisOrfermentation
棕霉素
Bruneomycin Finaltitre150mg/l
Fermentationtime144hrs
Recoveryyield60%
放线菌素D
DactinomycinDChemicalsynthesis
表阿霉素
Epirubicin Chemicalsynthesis
伊达比星
Idarubicin Chemicalsynthesis
吡柔比星
PirarubicinChemicalsynthesis
ANTI-CARDIVASCULAR
洛伐他汀
LovastatinFinalTitre:
16g/L
FermentationTime:
168hrs
Recovery:
70%
美伐他汀
CompactinFinalTitre:
10g/L
FermentationTime:
200-220hrs
普伐他汀
PravastatinFinalTitre:
8.0g/l
Conversionrate:
70%
Cycletime:
120-144
阿托伐他汀
AtorvastatinChemicalsynthesis
瑞舒伐他汀
RosuvastatinChemicalsynthesis
辛伐他汀
SimvastatinChemicalsynthesis
氟伐他汀
FluvastatinChemicalsynthesis
ORGANNICACID
Biobasedchemicals
衣康酸
ItaconicAcidAcid:
>6%
Cycletime:
40-50hrs
Conversion:
>50%
Fermentationdata:
1.4g/L/hrTheproductgetstoPfizer
柠檬酸
Citricacid
莽草酸
ShikimicAcidTitre:
25g/L
L-乳酸
L-LacticacidAcid:
16-18%
Conversionrate;90%
丙酮酸
PyruvicacidTitre:
55-65g/L
Conversionrate:
55-60%
Fermentationtime:
60hr
Recovery:
70%
长链二元酸
Long-chaindicarbxylicacidDCA13-18:
180g/L,
Fermentationtime:
5-6days
Bio-basedproducts
1,3-丙二醇
1,3-propandiol(PDO)Titre:
85g/L
Conversionrate:
60%
Productivity:
1.2-1.4g/LHChemical
2,3-丁二醇
2,3-butandiol 50-65g/LByproductfromPDO
丁醇
Butanol 20g/L
甘油
GlycerolTitre:
160g/l
Time:
78hrs
Productivity:
2g/LH
Massconversionrate:
48.6%Chemical
丙烯酰胺
AcrylamideEnzymeactivity:
10g/ml
Acrylonitrileconsumption:
0.75t/t
Conversionrate:
99.9%Chemical
烟酰胺
NicotinamideEnzymeactivity:
8g/ml
Nicotinonitrileconsumption:
0.85t/t
Conversionrate:
99.999%
Assay:
100%Chemical
羟基乙酸
HydroxyaceticacidEnzymeactivity:
0.1g/ml
Glycolonitrileconsumption:
0.78t/t
Conversionrate:
99.9%
Assay:
99.5%(pharmagrade)Chemical
黄原胶
XanthanFinalTitre:
5-6g/L
FermentationTime:
36hrs
Recovery:
80%
琥珀酸(丁二酸)
Succinicacid
苹果酸
Malicacid
牛磺酸
Taurine
乙酸(醋酸)
Aceticacid
聚羟基脂肪酸
Polyhydroxyalkanoates(PHAs)
degradableplastics
聚乳酸
Polylacticacid,PLA
VITAMINANDCAROTENOID
维生素B2
VitaminB2Finaltitre30g/l
Fermentationtime72hrs
Recoveryyield80%
维生素B12
VitaminB12Finaltitre250mg/l
TIME:
180hrs
维生素C
VitaminCFinaltitre11-12g/l
Fermentationtime60hrs
Conversionrate;90%
番茄红素
LycopeneFinalTitre:
>1.0g/L
胡萝卜素
BetaCaroteneFinalTitre:
2.5-3.0g/L
FermentationTime:
72hrs
Recovery:
75-80%
虾青素Astaxanthin FinalTitre:
2g/L
维生素D2
VitaminD2Lightreaction
维生素D3
VitaminD3Lightreaction
维生素A
VitaminAchemicalsynthesis
维生素H
VitaminHByfermentation
Orchemicalsynthesis Biotin
H
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